Estrogen use and brain metabolic change in older adults. A preliminary report.

TitleEstrogen use and brain metabolic change in older adults. A preliminary report.
Publication TypeJournal Article
Year of Publication2001
AuthorsRasgon, NL, Small GW, Siddarth P, Miller K, Ercoli LM, Bookheimer SY, Lavretsky H, Huang SC, Barrio JR, Phelps ME
JournalPsychiatry research
Date Published2001 Jul 1
KeywordsAged, Aged, 80 and over, Aging, Analysis of Variance, Brain, Estrogen Replacement Therapy, Estrogens, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Radiopharmaceuticals, Temporal Lobe, Tomography, Emission-Computed, Treatment Outcome

Because estrogen may influence brain blood flow and metabolism in older adults, we used positron emission tomography to evaluate cerebral glucose metabolic change in post-menopausal women and men. Women estrogen users (n=4), women non-users (n=8) and men (n=10) were scanned at baseline and two years later. Analyses focused on glucose metabolism in lateral temporal, inferior parietal and posterior cingulate brain regions, previously reported to decline in non-demented older persons. No metabolic differences in cerebral regions of interest were found among groups at baseline. At follow-up, women estrogen users showed significantly increased glucose metabolism in the lateral temporal region, whereas women non-users and men exhibited no significant metabolic change in this region. These findings suggest that estrogen use may protect against regional cerebral metabolic decline in postmenopausal women.

Alternate JournalPsychiatry Res