Right lateral fusiform gyrus dysfunction during facial information processing in schizophrenia.

TitleRight lateral fusiform gyrus dysfunction during facial information processing in schizophrenia.
Publication TypeJournal Article
Year of Publication2003
AuthorsQuintana, J, Wong T, Ortiz-Portillo E, Marder SR, Mazziotta JC
JournalBiological psychiatry
Volume53
Issue12
Pagination1099-112
Date Published2003 Jun 15
ISSN0006-3223
KeywordsAdult, Attention, Brain Mapping, cerebral cortex, Discrimination Learning, Facial Expression, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Recognition (Psychology), Schizophrenia, Schizophrenic Psychology, Semantics
Abstract

Patients with schizophrenia exhibit facial information processing deficits that likely contribute to their social dysfunction. Whether the deficits involve facial affect and/or identity processing or result from other cognitive abnormalities in schizophrenia remains controversial, and a brain dysfunction specifically related to them has never been reported. If such dysfunction existed, it should be consistently observed across groups of patients and during performance of different facial information processing tasks, independently of whether such tasks demand working memory (WM), semantic, or other cognitive processes. We hypothesized that the right lateral fusiform gyrus (rLFG), one of several human brain areas involved in facial information processing, would consistently show activation abnormalities during both facial affect and identity discrimination in schizophrenia.

DOI10.1002/jts.20444
Alternate JournalBiol. Psychiatry