Right lateral fusiform gyrus dysfunction during facial information processing in schizophrenia.
|Title||Right lateral fusiform gyrus dysfunction during facial information processing in schizophrenia.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Quintana, J, Wong T, Ortiz-Portillo E, Marder SR, Mazziotta JC|
|Date Published||2003 Jun 15|
|Keywords||Adult, Attention, Brain Mapping, cerebral cortex, Discrimination Learning, Facial Expression, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Recognition (Psychology), Schizophrenia, Schizophrenic Psychology, Semantics|
Patients with schizophrenia exhibit facial information processing deficits that likely contribute to their social dysfunction. Whether the deficits involve facial affect and/or identity processing or result from other cognitive abnormalities in schizophrenia remains controversial, and a brain dysfunction specifically related to them has never been reported. If such dysfunction existed, it should be consistently observed across groups of patients and during performance of different facial information processing tasks, independently of whether such tasks demand working memory (WM), semantic, or other cognitive processes. We hypothesized that the right lateral fusiform gyrus (rLFG), one of several human brain areas involved in facial information processing, would consistently show activation abnormalities during both facial affect and identity discrimination in schizophrenia.
|Alternate Journal||Biol. Psychiatry|