Spatial working memory function in twins with schizophrenia and bipolar disorder.
|Title||Spatial working memory function in twins with schizophrenia and bipolar disorder.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Pirkola, T, Tuulio-Henriksson A, Glahn D, Kieseppä T, Haukka J, Kaprio J, Lönnqvist J, Cannon TD|
|Date Published||2005 Dec 15|
|Keywords||Aged, Bipolar disorder, Cohort Studies, Education, Female, Finland, Humans, Intelligence, Linear Models, Male, Memory, Short-Term, Middle Aged, Psychiatric Status Rating Scales, Schizophrenic Psychology, Space Perception, Twins|
Family studies are in conflict as to whether schizophrenia and bipolar disorder have independent genetic etiologies. Given the relatively low prevalence (approximately 1%) of these disorders, the use of quantitative endophenotypic markers of genetic liability might provide a more sensitive strategy for evaluating their genetic overlap. We have previously demonstrated that spatial working memory deficits increase in a dose-dependent fashion with increasing genetic proximity to a proband among the unaffected co-twins of schizophrenic patients. Here, we evaluated whether such deficits might also mark genetic susceptibility to bipolar disorder.
|Alternate Journal||Biol. Psychiatry|