Spatial working memory function in twins with schizophrenia and bipolar disorder.

TitleSpatial working memory function in twins with schizophrenia and bipolar disorder.
Publication TypeJournal Article
Year of Publication2005
AuthorsPirkola, T, Tuulio-Henriksson A, Glahn D, Kieseppä T, Haukka J, Kaprio J, Lönnqvist J, Cannon TD
JournalBiological psychiatry
Volume58
Issue12
Pagination930-6
Date Published2005 Dec 15
ISSN0006-3223
KeywordsAged, Bipolar disorder, Cohort Studies, Education, Female, Finland, Humans, Intelligence, Linear Models, Male, Memory, Short-Term, Middle Aged, Psychiatric Status Rating Scales, Schizophrenic Psychology, Space Perception, Twins
Abstract

Family studies are in conflict as to whether schizophrenia and bipolar disorder have independent genetic etiologies. Given the relatively low prevalence (approximately 1%) of these disorders, the use of quantitative endophenotypic markers of genetic liability might provide a more sensitive strategy for evaluating their genetic overlap. We have previously demonstrated that spatial working memory deficits increase in a dose-dependent fashion with increasing genetic proximity to a proband among the unaffected co-twins of schizophrenic patients. Here, we evaluated whether such deficits might also mark genetic susceptibility to bipolar disorder.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalBiol. Psychiatry