In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.
|Title||In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.|
|Publication Type||Journal Article|
|Year of Publication||1999|
|Authors||Park, SP, Lopez-Rodriguez F, Wilson CL, Maidment N, Matsumoto Y, Engel J|
|Date Published||1999 Jul 3|
|Keywords||Animals, Extracellular Space, Hippocampus, Male, microdialysis, Rats, Rats, Sprague-Dawley, Serotonin, Sleep, REM, Wakefulness|
We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.
|Alternate Journal||Brain Res.|