In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.

TitleIn vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.
Publication TypeJournal Article
Year of Publication1999
AuthorsPark, SP, Lopez-Rodriguez F, Wilson CL, Maidment N, Matsumoto Y, Engel J
JournalBrain research
Volume833
Issue2
Pagination291-6
Date Published1999 Jul 3
ISSN0006-8993
KeywordsAnimals, Extracellular Space, Hippocampus, Male, microdialysis, Rats, Rats, Sprague-Dawley, Serotonin, Sleep, REM, Wakefulness
Abstract

We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.

DOI10.3791/1355
Alternate JournalBrain Res.