Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus.

TitleThree-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus.
Publication TypeJournal Article
Year of Publication2009
AuthorsOgren, JA, Wilson CL, Bragin A, Lin JJ, Salamon N, Dutton RA, Luders E, Fields TA, Fried I, Toga AW, Thompson PM, Engel J, Staba RJ
JournalAnnals of neurology
Volume66
Issue6
Pagination783-91
Date Published2009 Dec
ISSN1531-8249
KeywordsAdult, Atrophy, Brain Mapping, Electroencephalography, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult
Abstract

There is compelling evidence that pathological high-frequency oscillations (HFOs), called fast ripples (FR, 150-500Hz), reflect abnormal synchronous neuronal discharges in areas responsible for seizure genesis in patients with mesial temporal lobe epilepsy (MTLE). It is hypothesized that morphological changes associated with hippocampal atrophy (HA) contribute to the generation of FR, yet there is limited evidence that hippocampal FR-generating sites correspond with local areas of atrophy.

DOI10.1111/j.1528-1167.2011.03065.x
Alternate JournalAnn. Neurol.