Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns.

TitleThree-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns.
Publication TypeJournal Article
Year of Publication2009
AuthorsOgren, JA, Bragin A, Wilson CL, Hoftman GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Staba RJ
JournalEpilepsia
Volume50
Issue6
Pagination1361-70
Date Published2009 Jun
ISSN1528-1167
KeywordsAdolescent, Adult, Age of Onset, Atrophy, Brain Mapping, Child, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Middle Aged, Seizures, Young Adult
Abstract

Current evidence suggests that the mechanisms underlying depth electrode-recorded seizures beginning with hypersynchronous (HYP) onset patterns are functionally distinct from those giving rise to low-voltage fast (LVF) onset seizures. However, both groups have been associated with hippocampal atrophy (HA), indicating a need to clarify the anatomic correlates of each ictal onset type. We used three-dimensional (3D) hippocampal mapping to quantify HA and determine whether each onset group exhibited a unique distribution of atrophy consistent with the functional differences that distinguish the two onset morphologies.

DOI10.1111/j.1528-1167.2011.03065.x
Alternate JournalEpilepsia