Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns.
|Title||Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Ogren, JA, Bragin A, Wilson CL, Hoftman GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Staba RJ|
|Date Published||2009 Jun|
|Keywords||Adolescent, Adult, Age of Onset, Atrophy, Brain Mapping, Child, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Middle Aged, Seizures, Young Adult|
Current evidence suggests that the mechanisms underlying depth electrode-recorded seizures beginning with hypersynchronous (HYP) onset patterns are functionally distinct from those giving rise to low-voltage fast (LVF) onset seizures. However, both groups have been associated with hippocampal atrophy (HA), indicating a need to clarify the anatomic correlates of each ictal onset type. We used three-dimensional (3D) hippocampal mapping to quantify HA and determine whether each onset group exhibited a unique distribution of atrophy consistent with the functional differences that distinguish the two onset morphologies.