1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia.

Title1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia.
Publication TypeJournal Article
Year of Publication2004
AuthorsO'Neill, J, Levitt J, Caplan R, Asarnow R, McCracken JT, Toga AW, Alger JR
JournalNeuroImage
Volume21
Issue4
Pagination1781-9
Date Published2004 Apr
ISSN1053-8119
KeywordsAdolescent, Age Factors, Aspartic Acid, Brain, Brain Mapping, Caudate Nucleus, Child, Choline, Creatine, Dominance, Cerebral, Energy Metabolism, Frontal Lobe, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Phosphocreatine, Reference Values, Schizophrenia, Schizophrenic Psychology, Sex Factors, Thalamus
Abstract

In adult schizophrenia, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have revealed volumetric and metabolic defects in multiple brain regions, among them the anterior cingulate, frontal cortex, striatum, thalamus, parietal cortex, and frontal and parietal white matter. This study used proton magnetic resonance spectroscopic imaging ((1)H MRSI) to identify potential metabolic abnormalities in these regions in childhood-onset schizophrenia. (1)H MRSI was acquired at 1.5 T and 272 ms echo time in 11 children and adolescents with schizophrenia (aged 7-18 years; seven boys, four girls; all but two medicated) and 20 age-matched healthy controls (10 boys, 10 girls). Absolute levels of N-acetyl compounds (NAA), creatine plus phosphocreatine (Cr), and choline compounds (Cho) were compared among groups in each region. In schizophrenic patients relative to controls, Cr was 14.3% higher in superior anterior cingulate (mean of left and right hemispheres). Cho was higher in superior anterior cingulate (30.3%), frontal cortex (13.3%), and caudate head (13.5%). In the thalamus, there was also a diagnosis-by-gender interaction, whereby NAA was lower in patients for male but not for female subjects. Elevated Cr suggests abnormal local cell-energy demand and elevated Cho is consistent with a prior proposal that patients with early age-of-onset schizophrenia exhibit phospholipid membrane disturbances. Low NAA may reflect diminished neuronal integrity.

DOI10.1002/hbm.21441
Alternate JournalNeuroimage