Reduction in distractibility with AF102B and THA in the macaque.

TitleReduction in distractibility with AF102B and THA in the macaque.
Publication TypeJournal Article
Year of Publication2003
AuthorsO'Neill, J, Siembieda DW, Crawford CK, Halgren E, Fisher A, Fitten JL
JournalPharmacology, biochemistry, and behavior
Volume76
Issue2
Pagination301-6
Date Published2003 Sep
ISSN0091-3057
KeywordsAnimals, Attention, Cholinesterase Inhibitors, Conditioning, Operant, Female, Macaca radiata, Male, Muscarinic Agonists, Nootropic Agents, Psychomotor Performance, Quinuclidines, Space Perception, Tacrine, Thiophenes, Visual Perception
Abstract

Distractibility in primates may be influenced by central cholinergic systems. Two cholinomimetics, the m-1 muscarinic agonist (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine (AF102B, civemeline) and the cholinesterase inhibitor tetrahydroaminoacridine (THA, tacrine), were compared to vehicle controls for effects on distractibility in an automated visuospatial attention task. The task required visual pursuit of a moving target amongst distractor stimuli that acted to impair performance and was executed by seven healthy adult bonnet macaque monkeys. Task accuracy and reaction time were measured 1.5 h after systemic administration of each substance. For the seven-subject group at individually titrated best doses, accuracy increased significantly relative to vehicle for both drugs. Reaction time at best dose decreased for both drugs, but not significantly. Muscarinic agonists and cholinesterase inhibitors may reduce distractibility in primates.

DOI10.1042/AN20110027
Alternate JournalPharmacol. Biochem. Behav.