ADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2.
|Title||ADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Nyman, ES, Ogdie MN, Loukola A, Varilo T, Taanila A, Hurtig T, Moilanen IK, Loo SK, McGough JJ, Järvelin M-R, Smalley SL, Nelson SF, Peltonen L|
|Journal||Journal of the American Academy of Child and Adolescent Psychiatry|
|Date Published||2007 Dec|
|Keywords||Adolescent, Alleles, Attention Deficit Disorder with Hyperactivity, Cohort Studies, Diagnostic and Statistical Manual of Mental Disorders, DNA Primers, Dopamine beta-Hydroxylase, Female, Genetic Markers, Genotype, Humans, Male, Polymorphism, Genetic, Population Surveillance, Receptors, Dopamine D3|
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset disorder with a significant impact on public health. Although a genetic contribution to risk is evident, predisposing genetic determinants remain largely unknown despite extensive research. So far, the most promising candidate genes have been those involved in dopamine and serotonin pathways. This study tests a series of allelic variants within such candidate genes to determine their potential influence on ADHD susceptibility.
|Alternate Journal||J Am Acad Child Adolesc Psychiatry|