ADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2.

TitleADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2.
Publication TypeJournal Article
Year of Publication2007
AuthorsNyman, ES, Ogdie MN, Loukola A, Varilo T, Taanila A, Hurtig T, Moilanen IK, Loo SK, McGough JJ, Järvelin M-R, Smalley SL, Nelson SF, Peltonen L
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume46
Issue12
Pagination1614-21
Date Published2007 Dec
ISSN0890-8567
KeywordsAdolescent, Alleles, Attention Deficit Disorder with Hyperactivity, Cohort Studies, Diagnostic and Statistical Manual of Mental Disorders, DNA Primers, Dopamine beta-Hydroxylase, Female, Genetic Markers, Genotype, Humans, Male, Polymorphism, Genetic, Population Surveillance, Receptors, Dopamine D3
Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset disorder with a significant impact on public health. Although a genetic contribution to risk is evident, predisposing genetic determinants remain largely unknown despite extensive research. So far, the most promising candidate genes have been those involved in dopamine and serotonin pathways. This study tests a series of allelic variants within such candidate genes to determine their potential influence on ADHD susceptibility.

DOI10.1111/j.1553-2712.2011.01024.x
Alternate JournalJ Am Acad Child Adolesc Psychiatry