Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13.
|Title||Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Nurmi, EL, Dowd M, Tadevosyan-Leyfer O, Haines JL, Folstein SE, Sutcliffe JS|
|Journal||Journal of the American Academy of Child and Adolescent Psychiatry|
|Date Published||2003 Jul|
|Keywords||Autistic Disorder, Child, Chromosomes, Human, Pair 15, cognition, Factor Analysis, Statistical, Female, Gene Expression, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Humans, Male, Phenotype, Receptors, GABA|
Autism displays a remarkably high heritability but a complex genetic etiology. One approach to identifying susceptibility loci under these conditions is to define more homogeneous subsets of families on the basis of genetically relevant phenotypic or biological characteristics that vary from case to case.
|Alternate Journal||J Am Acad Child Adolesc Psychiatry|