Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13.

TitleExploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13.
Publication TypeJournal Article
Year of Publication2003
AuthorsNurmi, EL, Dowd M, Tadevosyan-Leyfer O, Haines JL, Folstein SE, Sutcliffe JS
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume42
Issue7
Pagination856-63
Date Published2003 Jul
ISSN0890-8567
KeywordsAutistic Disorder, Child, Chromosomes, Human, Pair 15, cognition, Factor Analysis, Statistical, Female, Gene Expression, Genetic Linkage, Genetic Predisposition to Disease, Genotype, Humans, Male, Phenotype, Receptors, GABA
Abstract

Autism displays a remarkably high heritability but a complex genetic etiology. One approach to identifying susceptibility loci under these conditions is to define more homogeneous subsets of families on the basis of genetically relevant phenotypic or biological characteristics that vary from case to case.

DOI10.1111/j.1751-7893.2011.00317.x
Alternate JournalJ Am Acad Child Adolesc Psychiatry