Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone.

TitleTreatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone.
Publication TypeJournal Article
Year of Publication2006
AuthorsNierenberg, AA, Ostacher MJ, Calabrese JR, Ketter TA, Marangell LB, Miklowitz DJ, Miyahara S, Bauer MS, Thase ME, Wisniewski SR, Sachs GS
JournalThe American journal of psychiatry
Volume163
Issue2
Pagination210-6
Date Published2006 Feb
ISSN0002-953X
KeywordsAdult, Anticonvulsants, Antidepressive Agents, Antipsychotic Agents, Bipolar disorder, Depressive Disorder, Major, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Inositol, Male, Middle Aged, Psychiatric Status Rating Scales, Risperidone, Treatment Outcome, Triazines, Vitamin B Complex
Abstract

Clinicians have few evidence-based options for the management of treatment-resistant bipolar depression. This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone.

DOI10.1038/npp.2011.192
Alternate JournalAm J Psychiatry