Genome-wide association study identifies eight loci associated with blood pressure.

TitleGenome-wide association study identifies eight loci associated with blood pressure.
Publication TypeJournal Article
Year of Publication2009
AuthorsNewton-Cheh, C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Hua Zhao J, Heath SC, Eyheramendy S et al.
Corporate AuthorsWellcome Trust Case Control Consortium
JournalNature genetics
Volume41
Issue6
Pagination666-76
Date Published2009 Jun
ISSN1546-1718
KeywordsBlood Pressure, Cardiovascular Diseases, Chromosome Mapping, Cytochrome P-450 CYP1A2, Diastole, DNA-Binding Proteins, Europe, European Continental Ancestry Group, Fibroblast Growth Factor 5, Genetic Variation, Genome-Wide Association Study, Humans, India, Methylenetetrahydrofolate Reductase (NADPH2), Open Reading Frames, Phospholipase C delta, Polymorphism, Single Nucleotide, Proteins, Steroid 17-alpha-Hydroxylase, Systole
Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

DOI10.1042/AN20110027
Alternate JournalNat. Genet.