Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome.

TitlePositron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome.
Publication TypeJournal Article
Year of Publication2011
AuthorsNelson, LD, Siddarth P, Kepe V, Scheibel KE, Huang SC, Barrio JR, Small GW
JournalArchives of neurology
Volume68
Issue6
Pagination768-74
Date Published2011 Jun
ISSN1538-3687
KeywordsAdult, Aged, Alzheimer Disease, Amyloid beta-Peptides, Cross-Sectional Studies, Down Syndrome, Female, Humans, Male, Middle Aged, Plaque, Amyloid, Positron-Emission Tomography, Protein Binding, tau Proteins, Young Adult
Abstract

To determine the neuropathological load in the living brain of nondemented adults with Down syndrome using positron emission tomography with 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) and to assess the influence of age and cognitive and behavioral functioning. For reference, [(18)F]FDDNP binding values and patterns were compared with those from patients with Alzheimer disease and cognitively intact control participants.

Alternate JournalArch. Neurol.