Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.

TitleMeta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.
Publication TypeJournal Article
Year of Publication2010
AuthorsNeale, BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch K-P, Faraone SV, Nguyen TT, Schäfer H, Holmans P, Daly M, Steinhausen H-C, Freitag C, Reif A, Renner TJ, Romanos M, Romanos J, Walitza S, Warnke A, Meyer J, Palmason H, Buitelaar J, Vasquez AA, Lambregts-Rommelse N, Gill M, Anney RJL, Langely K, O'Donovan M, Williams N, Owen M, Thapar A, Kent L, Sergeant J, Roeyers H, Mick E, Biederman J, Doyle A, Smalley S, Loo S, Hakonarson H, Elia J, Todorov A, Miranda A, Mulas F, Ebstein RP, Rothenberger A, Banaschewski T, Oades RD, Sonuga-Barke E, McGough J, Nisenbaum L, Middleton F, Hu X, Nelson S
Corporate AuthorsPsychiatric GWAS Consortium: ADHD Subgroup
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume49
Issue9
Pagination884-97
Date Published2010 Sep
ISSN1527-5418
KeywordsAdolescent, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Female, Genetic Association Studies, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide
Abstract

Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power.

DOI10.1001/archgenpsychiatry.2011.51
Alternate JournalJ Am Acad Child Adolesc Psychiatry