Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.

TitleYoung dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.
Publication TypeJournal Article
Year of Publication2012
AuthorsNakashiba, T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, Tonegawa S
JournalCell
Volume149
Issue1
Pagination188-201
Date Published2012 Mar 30
ISSN1097-4172
KeywordsAging, Animals, Chromosome Pairing, Dentate Gyrus, Green Fluorescent Proteins, Hippocampus, memory, Mice, Mice, Transgenic
Abstract

Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from less active, older adult-born GCs and the major population of dentate GCs generated developmentally. To ascertain whether young and old GCs perform distinct memory functions, we created a transgenic mouse in which output of old GCs was specifically inhibited while leaving a substantial portion of young GCs intact. These mice exhibited enhanced or normal pattern separation between similar contexts, which was reduced following ablation of young GCs. Furthermore, these mutant mice exhibited deficits in rapid pattern completion. Therefore, pattern separation requires adult-born young GCs but not old GCs, and older GCs contribute to the rapid recall by pattern completion. Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion.

DOI10.1002/hipo.20954
Alternate JournalCell