Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene.

TitleHeroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene.
Publication TypeJournal Article
Year of Publication2002
AuthorsMurphy, NP, Lam HA, Chen Z, Pintar JE, Maidment NT
JournalBrain research
Volume953
Issue1-2
Pagination276-80
Date Published2002 Oct 25
ISSN0006-8993
KeywordsAnalgesics, Opioid, Animals, Dopamine, Heroin, Limbic System, Mice, Mice, Knockout, Motor Activity, Opioid Peptides, Receptors, Opioid
Abstract

We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.

DOI10.3791/1355
Alternate JournalBrain Res.