Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene.
|Title||Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Murphy, NP, Lam HA, Chen Z, Pintar JE, Maidment NT|
|Date Published||2002 Oct 25|
|Keywords||Analgesics, Opioid, Animals, Dopamine, Heroin, Limbic System, Mice, Mice, Knockout, Motor Activity, Opioid Peptides, Receptors, Opioid|
We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.
|Alternate Journal||Brain Res.|