Blood pressure elevation in rats by peripheral administration of Tyr-Gly-Gly-Phe-Met-Arg-Phe and the invertebrate neuropeptide, Phe-Met-Arg-Phe-NH2.

TitleBlood pressure elevation in rats by peripheral administration of Tyr-Gly-Gly-Phe-Met-Arg-Phe and the invertebrate neuropeptide, Phe-Met-Arg-Phe-NH2.
Publication TypeJournal Article
Year of Publication1982
AuthorsMues, G, Fuchs I, Wei ET, Weber E, Evans CJ, Barchas JD, Chang JK
JournalLife sciences
Volume31
Issue23
Pagination2555-61
Date Published1982 Dec 6
ISSN0024-3205
KeywordsAnimals, Blood Pressure, Enkephalin, Methionine, FMRFamide, Heart Rate, Injections, Intravenous, Male, Oligopeptides, Rats, Rats, Inbred Strains, Respiration, Stereoisomerism, Stimulation, Chemical, Vascular Resistance
Abstract

Phe-Met-Arg-Phe-NH2 (FMRFamide), injected at less than 1 mumol/kg intravenously in the anesthetized rat, produces sharp elevations of blood pressure and changes in respiration. The effects were dependent on the carboxyterminal Arg-Phe (RF) configuration and were stereospecific for these two amino acids. A related peptide with RF carboxyterminus, gamma 1-melanotropic stimulating hormone, also had potent blood pressure stimulating activity. The mechanisms underlying the pressor effect of FMRFamide have not yet been established but this pressor action was not significantly attenuated by standard pharmacologic antagonists or prevented by removal of the adrenal or pituitary gland.

DOI10.1002/hipo.20954
Alternate JournalLife Sci.