Neurophysiologic changes during estrogen augmentation in perimenopausal depression.
|Title||Neurophysiologic changes during estrogen augmentation in perimenopausal depression.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Morgan, ML, Cook IA, Rapkin AJ, Leuchter AF|
|Date Published||2007 Jan 20|
|Keywords||Administration, Oral, Adult, Antidepressive Agents, Depression, Electroencephalography, Estrogen Replacement Therapy, Female, Frontal Lobe, Humans, Middle Aged, Perimenopause|
Estrogen augmentation of antidepressant medication has been an effective treatment in a subgroup of women experiencing affective symptoms during perimenopause. It has been suggested that estrogen facilitates serotonergic transmission in brain regions involved in mood disorders. We investigated differences in physiologic brain changes with estrogen augmentation in women with perimenopausal depression who reached remission compared to those who did not reach remission. We also assessed whether such changes were correlated with serum hormone levels.