Neurophysiologic changes during estrogen augmentation in perimenopausal depression.

TitleNeurophysiologic changes during estrogen augmentation in perimenopausal depression.
Publication TypeJournal Article
Year of Publication2007
AuthorsMorgan, ML, Cook IA, Rapkin AJ, Leuchter AF
JournalMaturitas
Volume56
Issue1
Pagination54-60
Date Published2007 Jan 20
ISSN0378-5122
KeywordsAdministration, Oral, Adult, Antidepressive Agents, Depression, Electroencephalography, Estrogen Replacement Therapy, Female, Frontal Lobe, Humans, Middle Aged, Perimenopause
Abstract

Estrogen augmentation of antidepressant medication has been an effective treatment in a subgroup of women experiencing affective symptoms during perimenopause. It has been suggested that estrogen facilitates serotonergic transmission in brain regions involved in mood disorders. We investigated differences in physiologic brain changes with estrogen augmentation in women with perimenopausal depression who reached remission compared to those who did not reach remission. We also assessed whether such changes were correlated with serum hormone levels.

DOI10.1042/AN20110063
Alternate JournalMaturitas