An implicit learning task activates medial temporal lobe in patients with Parkinson's disease.

TitleAn implicit learning task activates medial temporal lobe in patients with Parkinson's disease.
Publication TypeJournal Article
Year of Publication2004
AuthorsMoody, TD, Bookheimer SY, Vanek Z, Knowlton BJ
JournalBehavioral neuroscience
Volume118
Issue2
Pagination438-42
Date Published2004 Apr
ISSN0735-7044
KeywordsBasal Ganglia, Caudate Nucleus, Corpus Striatum, Cues, Female, Habituation, Psychophysiologic, Humans, Learning, Magnetic Resonance Imaging, Male, memory, Middle Aged, Parkinson Disease, Prefrontal Cortex, ROC Curve, Temporal Lobe
Abstract

Recent studies provide evidence for an interaction between a declarative memory system, dependent on the medial temporal lobe (MTL), and a habit memory system, dependent on the basal ganglia. Using functional MRI, the authors studied this interaction when 1 system was compromised by neurological disease. Neural activity when performing a habit-learning task was compared in normal controls and subjects with Parkinson's disease (PD). Patients with PD showed less activation in the caudate nucleus and greater activation in a region of prefrontal cortex that has been associated with explicit memory retrieval. Patients with PD also showed activation of the MTL during the weather-prediction task. These findings are consistent with an interaction between memory systems of the MTL and the striatum.

Alternate JournalBehav. Neurosci.