An implicit learning task activates medial temporal lobe in patients with Parkinson's disease.
|Title||An implicit learning task activates medial temporal lobe in patients with Parkinson's disease.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Moody, TD, Bookheimer SY, Vanek Z, Knowlton BJ|
|Date Published||2004 Apr|
|Keywords||Basal Ganglia, Caudate Nucleus, Corpus Striatum, Cues, Female, Habituation, Psychophysiologic, Humans, Learning, Magnetic Resonance Imaging, Male, memory, Middle Aged, Parkinson Disease, Prefrontal Cortex, ROC Curve, Temporal Lobe|
Recent studies provide evidence for an interaction between a declarative memory system, dependent on the medial temporal lobe (MTL), and a habit memory system, dependent on the basal ganglia. Using functional MRI, the authors studied this interaction when 1 system was compromised by neurological disease. Neural activity when performing a habit-learning task was compared in normal controls and subjects with Parkinson's disease (PD). Patients with PD showed less activation in the caudate nucleus and greater activation in a region of prefrontal cortex that has been associated with explicit memory retrieval. Patients with PD also showed activation of the MTL during the weather-prediction task. These findings are consistent with an interaction between memory systems of the MTL and the striatum.
|Alternate Journal||Behav. Neurosci.|