Abnormal movements are associated with poor psychosocial functioning in adolescents at high risk for psychosis.

TitleAbnormal movements are associated with poor psychosocial functioning in adolescents at high risk for psychosis.
Publication TypeJournal Article
Year of Publication2011
AuthorsMittal, VA, Jalbrzikowski M, Daley M, Roman C, Bearden CE, Cannon TD
JournalSchizophrenia research
Date Published2011 Aug
KeywordsAdolescent, Disease Progression, Dyskinesias, Female, Humans, Intelligence Tests, Longitudinal Studies, Male, Neuropsychological Tests, Predictive Value of Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Regression Analysis, Risk Factors, Schizotypal Personality Disorder, Social Adjustment, Young Adult

The period immediately preceding the onset of overt psychosis is characterized by a range of symptoms and behaviors including emerging attenuated psychosis, spontaneous movement abnormalities, and a broad decline in role and social functioning. Recent evidence suggests that basal ganglia dysfunction, which is implicated in the development of psychotic symptomatology, may manifest in the form of both movement abnormalities and deficits in processes integral to psychosocial functioning. However, little is known about the relationship between abnormal movement function and the observed psychosocial deficits. In the present study, 40 clinical high-risk participants meeting criteria for a prodromal syndrome were assessed for movement abnormalities and global role and social functioning at baseline. Role and social functioning were then followed up after a one-year period. At baseline, the severity of spontaneous movement abnormalities was associated with poor role functioning. Further, when controlling for baseline functioning, movement abnormalities predicted changes in social functioning one-year later, with a trend in the same direction for role functioning. Exploratory analyses also indicated that elevated baseline movement abnormalities distinguished those at-risk participants who eventually converted to psychosis and that this was also the case for poorer baseline global role functioning (at the trend level). Taken together, the results suggest that movement abnormalities are closely associated with deficits in psychosocial functioning. Elucidating the link between these phenomena may serve to refine etiological models of frontal-subcortical circuit dysfunction and inform understanding of functioning and outcome of these affected youth.

Alternate JournalSchizophr. Res.