Markers of basal ganglia dysfunction and conversion to psychosis: neurocognitive deficits and dyskinesias in the prodromal period.

TitleMarkers of basal ganglia dysfunction and conversion to psychosis: neurocognitive deficits and dyskinesias in the prodromal period.
Publication TypeJournal Article
Year of Publication2010
AuthorsMittal, VA, Walker EF, Bearden CE, Walder D, Trottman H, Daley M, Simone A, Cannon TD
JournalBiological psychiatry
Volume68
Issue1
Pagination93-9
Date Published2010 Jul 1
ISSN1873-2402
KeywordsAdolescent, Basal Ganglia, Cognition Disorders, Developmental Disabilities, Disease Progression, Dyskinesias, Female, Humans, Male, Movement Disorders, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Risk Factors, Statistics as Topic, Statistics, Nonparametric, Young Adult
Abstract

Movement abnormalities and cognitive deficits may represent external markers of an underlying neural process linked with the early etiology of psychosis. As basal ganglia function plays a governing role in both movement and cognitive processes, an understanding of the relationship between these phenomena stands to inform etiologic conceptualizations of vulnerability and psychotic disorders.

DOI10.1002/hbm.20991
Alternate JournalBiol. Psychiatry