Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls.

TitleIncreased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls.
Publication TypeJournal Article
Year of Publication2006
AuthorsMirza, Y, O'Neill J, Smith EA, Russell A, Smith JM, Banerjee PS, Bhandari R, Boyd C, Rose M, Ivey J, Renshaw PF, Rosenberg DR
JournalJournal of child neurology
Volume21
Issue2
Pagination106-11
Date Published2006 Feb
ISSN0883-0738
KeywordsAdolescent, Brain Mapping, Child, Creatine, Depressive Disorder, Major, Dominance, Cerebral, Energy Metabolism, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Obsessive-Compulsive Disorder, Phosphocreatine, Predictive Value of Tests, Reference Values, Thalamus
Abstract

Altered brain creatine-phosphocreatine levels might reflect changes in brain energy use and have been implicated in the pathogenesis of obsessive-compulsive disorder and major depressive disorder. We used proton magnetic resonance spectroscopy to measure absolute concentrations of creatine-phosphocreatine in the right and left medial thalami in 18 pediatric patients with major depressive disorder 9 to 17 years of age, 18 case-matched healthy controls, and 27 patients with obsessive-compulsive disorder 7 to 16 years old. The two patient groups were psychotropic drug naive and were not comorbid for the diagnosis of the comparison group. We found significantly increased left and right medial thalamic creatine-phosphocreatine concentrations in patients with obsessive-compulsive disorder compared with both healthy controls and patients with major depression. Creatine-phosphocreatine concentrations did not differ significantly between patients with major depression and healthy controls. Our data suggest that increased medial thalamic creatine-phosphocreatine concentrations in patients with untreated obsessive-compulsive disorder reflect altered energy use in the medial thalamus and might differentiate patients with obsessive-compulsive disorder from healthy controls and patients with major depression. Although these results must be considered preliminary, further study of the diagnostic specificity of creatine-phosphocreatine in obsessive-compulsive disorder is indicated.

DOI10.1111/j.1751-7893.2011.00317.x
Alternate JournalJ. Child Neurol.