Verbal memory retrieval deficits associated with untreated hypothyroidism.

TitleVerbal memory retrieval deficits associated with untreated hypothyroidism.
Publication TypeJournal Article
Year of Publication2007
AuthorsMiller, KJ, Parsons TD, Whybrow PC, Van Herle K, Rasgon N, Van Herle A, Martinez D, Silverman DH, Bauer M
JournalThe Journal of neuropsychiatry and clinical neurosciences
Volume19
Issue2
Pagination132-6
Date Published2007 Spring
ISSN0895-0172
KeywordsAdult, Female, Humans, Hypothyroidism, Male, Memory Disorders, Neuropsychological Tests, Severity of Illness Index, Vocabulary
Abstract

The effects of inadequate thyroid hormone availability to the brain on adult cognitive function are poorly understood. This study assessed the effects of hypothyroidism on cognitive function using a standard neuropsychological battery in 14 patients suffering from untreated hypothyroidism and complaining of subjective cognitive difficulties in comparison with 10 age-matched healthy comparison subjects. Significant differences between groups were limited to verbal memory retrieval as measured by the California Verbal Learning Test (CVLT). On short delay free recall, long delay free recall, and long delay cued recall, significant differences remained between groups despite the limited statistical power of this study. There were no significant results found between groups on attentional or nonverbal tasks. Results suggest that hypothyroid-related memory deficits are not attributable to an attentional deficit but rather to specific retrieval deficits.

DOI10.1038/npp.2011.192
Alternate JournalJ Neuropsychiatry Clin Neurosci