Memory improvement with treatment of hypothyroidism.

TitleMemory improvement with treatment of hypothyroidism.
Publication TypeJournal Article
Year of Publication2006
AuthorsMiller, KJ, Parsons TD, Whybrow PC, Van Herle K, Rasgon N, Van Herle A, Martinez D, Silverman DH, Bauer M
JournalThe International journal of neuroscience
Volume116
Issue8
Pagination895-906
Date Published2006 Aug
ISSN0020-7454
KeywordsAdolescent, Adult, Analysis of Variance, Female, Follow-Up Studies, Humans, Hypothyroidism, Male, Memory Disorders, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Prospective Studies, Thyroxine, Verbal Learning
Abstract

The consequences of inadequate thyroid hormone availability to the brain and treatment effects of levothyroxine on cognitive function are still poorly understood. This study prospectively assessed the effects of thyroid replacement therapy on cognitive function in patients suffering from biochemical evidenced, untreated hypothyroidism. Significant effects between the untreated hypothyroid group and control group were limited to verbal memory retrieval. When assessing the effects of 3-month treatment, results revealed that the treated hypothyroid group had significant increased verbal memory retrieval. Results suggest that specific memory retrieval deficits associated with hypothyroidism can resolve after replacement therapy with levothyroxine.

DOI10.1038/npp.2011.192
Alternate JournalInt. J. Neurosci.