The other side of estrogen replacement therapy: outcome study results of mood improvement in estrogen users and nonusers.

TitleThe other side of estrogen replacement therapy: outcome study results of mood improvement in estrogen users and nonusers.
Publication TypeJournal Article
Year of Publication2003
AuthorsMiller, KJ
JournalCurrent psychiatry reports
Volume5
Issue6
Pagination439-44
Date Published2003 Dec
ISSN1523-3812
KeywordsAffect, Alzheimer Disease, Brain, Climacteric, Clinical Trials as Topic, Cognition Disorders, Depressive Disorder, Estrogen Replacement Therapy, Female, Humans, Treatment Outcome
Abstract

The effect of estrogen on the brain and body of women is a controversial topic that has received a tremendous amount of attention in the past few years. Recent reviews have focused on hormone replacement therapy (HRT), medical risks, and effects on brain metabolism, cognition, risk of Alzheimer's disease, and mood. This article summarizes HRT and mood improvement in postmenopausal women. For nondepressed women, experimental designs provide no clear evidence for mood improvement associated with HRT, whereas observational studies are more likely to report mood improvement. There appears to be moderate evidence that HRT facilitates the improvement of clinical depression and the efficacy of antidepressants. Heterogeneity among studies makes it difficult to generalize and recommend HRT for mood improvement in postmenopausal women, but there is a clear need to examine the necessary duration of HRT for neuroprotection to decrease a woman's risk for depression, cognitive dysfunction, and development of Alzheimer's disease.

DOI10.1038/npp.2011.192
Alternate JournalCurr Psychiatry Rep