Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease.

TitlePropositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsMedina, LD, Rodriguez-Agudelo Y, Geschwind DH, Gilbert PE, Liang L-J, Cummings JL, Ringman JM
JournalDementia and geriatric cognitive disorders
Volume32
Issue3
Pagination188-92
Date Published2011
ISSN1421-9824
KeywordsAdult, Aging, Alzheimer Disease, Amyloid beta-Protein Precursor, Apolipoproteins E, Educational Status, Female, Genotype, Heterozygote, Humans, Language, Male, Mexican Americans, Mexico, Middle Aged, Mutation, Presenilin-1, Presenilin-2, Psychiatric Status Rating Scales, Regression Analysis, Risk, United States
Abstract

A relationship between decreased propositional density (p-density) in young adulthood and future risk for Alzheimer's disease (AD) has been postulated, but multiple interpretations of the nature of this relationship are possible. This study explored the relationship between familial AD (FAD) mutation status, apolipoprotein E (APOE) genotype, and p-density.

DOI10.1038/nn.3115
Alternate JournalDement Geriatr Cogn Disord