A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorder.

TitleA candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorder.
Publication TypeJournal Article
Year of Publication2009
AuthorsMcGough, JJ, McCracken JT, Loo SK, Manganiello M, Leung MC, Tietjens JR, Trinh T, Baweja S, Suddath R, Smalley SL, Hellemann G, Sugar CA
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume48
Issue12
Pagination1155-64
Date Published2009 Dec
ISSN1527-5418
KeywordsAchievement, Adolescent, Arousal, Attention Deficit Disorder with Hyperactivity, Catechol O-Methyltransferase, Central Nervous System Stimulants, Child, Cross-Over Studies, Dopamine Plasma Membrane Transport Proteins, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Exons, Female, Gene Dosage, Genetic Association Studies, Genotype, Humans, INDEL Mutation, Introns, Irritable Mood, Male, Mathematics, Methylphenidate, Minisatellite Repeats, Pharmacogenetics, Promoter Regions, Genetic, Prospective Studies, Receptors, Dopamine D4, Serotonin Plasma Membrane Transport Proteins, Synaptosomal-Associated Protein 25, Treatment Outcome
Abstract

This study examines the potential role of candidate genes in moderating treatment effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD).

DOI10.1001/archgenpsychiatry.2011.51
Alternate JournalJ Am Acad Child Adolesc Psychiatry