Gut feelings: the emerging biology of gut-brain communication.

TitleGut feelings: the emerging biology of gut-brain communication.
Publication TypeJournal Article
Year of Publication2011
AuthorsMayer, EA
JournalNature reviews. Neuroscience
Volume12
Issue8
Pagination453-66
Date Published2011 Aug
ISSN1471-0048
KeywordsBrain, Enteric Nervous System, Gastrointestinal Tract, Homeostasis, Humans
Abstract

The concept that the gut and the brain are closely connected, and that this interaction plays an important part not only in gastrointestinal function but also in certain feeling states and in intuitive decision making, is deeply rooted in our language. Recent neurobiological insights into this gut-brain crosstalk have revealed a complex, bidirectional communication system that not only ensures the proper maintenance of gastrointestinal homeostasis and digestion but is likely to have multiple effects on affect, motivation and higher cognitive functions, including intuitive decision making. Moreover, disturbances of this system have been implicated in a wide range of disorders, including functional and inflammatory gastrointestinal disorders, obesity and eating disorders.

DOI10.1038/ajg.2011.377
Alternate JournalNat. Rev. Neurosci.