Positron emission tomography metabolic correlates of apathy in Alzheimer disease.

TitlePositron emission tomography metabolic correlates of apathy in Alzheimer disease.
Publication TypeJournal Article
Year of Publication2007
AuthorsMarshall, GA, Monserratt L, Harwood D, Mandelkern M, Cummings JL, Sultzer DL
JournalArchives of neurology
Volume64
Issue7
Pagination1015-20
Date Published2007 Jul
ISSN0003-9942
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Mapping, Cerebrovascular Circulation, Energy Metabolism, Female, Fluorodeoxyglucose F18, Glucose, Gyrus Cinguli, Humans, Male, mood disorders, Neural Pathways, Neuropsychological Tests, Positron-Emission Tomography, Predictive Value of Tests, Prefrontal Cortex, Thalamus
Abstract

Apathy is the most common neuropsychiatric manifestation in Alzheimer disease (AD). Clinical, single-photon emission computed tomography, magnetic resonance imaging, and pathologic studies of apathy in AD have suggested an association with frontal dysfunction, most supportive of anterior cingulate abnormalities, but without a definitive localization.

DOI10.1111/j.1471-4159.2012.07732.x
Alternate JournalArch. Neurol.