Positron emission tomography metabolic correlates of apathy in Alzheimer disease.
|Title||Positron emission tomography metabolic correlates of apathy in Alzheimer disease.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Marshall, GA, Monserratt L, Harwood D, Mandelkern M, Cummings JL, Sultzer DL|
|Journal||Archives of neurology|
|Date Published||2007 Jul|
|Keywords||Aged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Mapping, Cerebrovascular Circulation, Energy Metabolism, Female, Fluorodeoxyglucose F18, Glucose, Gyrus Cinguli, Humans, Male, mood disorders, Neural Pathways, Neuropsychological Tests, Positron-Emission Tomography, Predictive Value of Tests, Prefrontal Cortex, Thalamus|
Apathy is the most common neuropsychiatric manifestation in Alzheimer disease (AD). Clinical, single-photon emission computed tomography, magnetic resonance imaging, and pathologic studies of apathy in AD have suggested an association with frontal dysfunction, most supportive of anterior cingulate abnormalities, but without a definitive localization.
|Alternate Journal||Arch. Neurol.|