Early-onset Alzheimer's disease is associated with greater pathologic burden.
|Title||Early-onset Alzheimer's disease is associated with greater pathologic burden.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Marshall, GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL|
|Journal||Journal of geriatric psychiatry and neurology|
|Date Published||2007 Mar|
|Keywords||Adult, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, cerebral cortex, Cohort Studies, Diagnosis, Differential, Dominance, Cerebral, Female, Humans, Male, Middle Aged, Neurofibrillary Tangles, Plaque, Amyloid, Retrospective Studies, Synapses|
Two subtypes of Alzheimer's disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P = .015; NFT: F = 7.5, df = 1, P = .012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.
|Alternate Journal||J Geriatr Psychiatry Neurol|