Early-onset Alzheimer's disease is associated with greater pathologic burden.

TitleEarly-onset Alzheimer's disease is associated with greater pathologic burden.
Publication TypeJournal Article
Year of Publication2007
AuthorsMarshall, GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL
JournalJournal of geriatric psychiatry and neurology
Date Published2007 Mar
KeywordsAdult, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, cerebral cortex, Cohort Studies, Diagnosis, Differential, Dominance, Cerebral, Female, Humans, Male, Middle Aged, Neurofibrillary Tangles, Plaque, Amyloid, Retrospective Studies, Synapses

Two subtypes of Alzheimer's disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P = .015; NFT: F = 7.5, df = 1, P = .012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.

Alternate JournalJ Geriatr Psychiatry Neurol