Neuropathologic correlates of apathy in Alzheimer's disease.

TitleNeuropathologic correlates of apathy in Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2006
AuthorsMarshall, GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL
JournalDementia and geriatric cognitive disorders
Date Published2006
KeywordsAged, Alzheimer Disease, Arousal, Brain, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Hippocampus, Humans, Male, Mental Disorders, Mental Status Schedule, Middle Aged, Motivation, Neurofibrillary Tangles, Occipital Lobe, Parietal Lobe, Plaque, Amyloid, Statistics as Topic, Temporal Lobe

Apathy is the most commonly observed behavioral disturbance in Alzheimer's disease (AD) and has been suggested to be frontally mediated. Neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were performed for 8 brain regions in 29 subjects with definite AD. Neuropsychiatric Inventory (NPI) for autopsied subjects was obtained from questioning of caregivers of subjects included in the study. Chronic apathy and total NPI composite scores correlated with anterior cingulate NFT counts (r = 0.518, p = 0.01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology.

Alternate JournalDement Geriatr Cogn Disord