Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.

TitleAssociation study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.
Publication TypeJournal Article
Year of Publication2009
AuthorsMansour, HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El-Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL
JournalBipolar disorders
Volume11
Issue7
Pagination701-10
Date Published2009 Nov
ISSN1399-5618
KeywordsAdult, Bipolar disorder, Circadian Rhythm, Circadian Rhythm Signaling Peptides and Proteins, Databases, Genetic, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Young Adult
Abstract

Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schizoaffective disorder (SZA) and schizophrenia (SZ). The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders.

Alternate JournalBipolar Disord