Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.
|Title||Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Mansour, HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El-Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL|
|Date Published||2009 Nov|
|Keywords||Adult, Bipolar disorder, Circadian Rhythm, Circadian Rhythm Signaling Peptides and Proteins, Databases, Genetic, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Young Adult|
Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schizoaffective disorder (SZA) and schizophrenia (SZ). The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders.
|Alternate Journal||Bipolar Disord|