The locus coeruleus complex of the bottlenose dolphin (Tursiops truncatus) as revealed by tyrosine hydroxylase immunohistochemistry.

TitleThe locus coeruleus complex of the bottlenose dolphin (Tursiops truncatus) as revealed by tyrosine hydroxylase immunohistochemistry.
Publication TypeJournal Article
Year of Publication2003
AuthorsManger, PR, Ridgway SH, Siegel JM
JournalJournal of sleep research
Volume12
Issue2
Pagination149-55
Date Published2003 Jun
ISSN0962-1105
KeywordsAnimals, Body Temperature Regulation, Catecholamines, Dolphins, Female, Immunohistochemistry, Locus Coeruleus, Norepinephrine, pons, Sleep, REM, Tyrosine 3-Monooxygenase
Abstract

Using tyrosine hydroxylase immunohistochemistry we examined the structure of the pontine, or rostral rhombencephalic, catecholaminergic cells groups, which may be collectively termed the locus coeruleus complex (LC), in the bottlenose dolphin. The present study is the first to describe the LC in a cetacean species and, at 1.3 kg, represents the largest non-human brain to date in which the LC has been investigated. We identified four catecholaminergic cell groups in the dorsal pontine tegementum and peri-aqueductal gray matter: A6 dorsal (locus coeruleus), A6 ventral (locus coeruleus alpha), A7 (subcoeruleus), and A5 (fifth arcuate nucleus). No patterns of cellular distribution, nuclear subdivision, or cellular morphology indicate specialization of the LC, which might have been anticipated because of the large absolute brain size and unihemispheric sleep phenomenology of cetaceans.

Alternate JournalJ Sleep Res