REM sleep deprivation reduces auditory evoked inhibition of dorsolateral pontine neurons.

TitleREM sleep deprivation reduces auditory evoked inhibition of dorsolateral pontine neurons.
Publication TypeJournal Article
Year of Publication1991
AuthorsMallick, BN, Fahringer HM, Wu MF, Siegel JM
JournalBrain research
Volume552
Issue2
Pagination333-7
Date Published1991 Jun 28
ISSN0006-8993
KeywordsAcoustic Stimulation, Animals, Cats, Clonidine, Evoked Potentials, Auditory, Female, Neurons, pons, sleep deprivation, Sleep, REM
Abstract

In many dorsolateral pontine neurons, auditory stimulation produces an initial excitation followed by a sustained inhibition. We now report that rapid eye movement (REM) sleep deprivation, for periods of from 22-48 h, reduced this auditory evoked inhibition of unit discharge. Inhibition returned to baseline levels after recovery REM sleep. Prior work indicates that the auditory evoked inhibition seen in noradrenergic cells in this region is partially mediated by norepinephrine. We hypothesize that the reduction in inhibition that we see is a consequence of either downregulation/desensitization of norepinephrine receptors or reduced norepinephrine release resulting from REM sleep deprivation.

DOI10.1111/j.1365-2869.2012.01023.x
Alternate JournalBrain Res.