Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats.

TitleOrphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats.
Publication TypeJournal Article
Year of Publication2001
AuthorsLutfy, K, Do T, Maidment NT
JournalPsychopharmacology
Volume154
Issue1
Pagination1-7
Date Published2001 Feb
ISSN0033-3158
KeywordsAnimals, Apomorphine, Cocaine, Dopamine, Dopamine Agonists, Dopamine Uptake Inhibitors, Excitatory Amino Acid Agonists, Extracellular Space, Injections, Intraventricular, microdialysis, Motor Activity, Nucleus Accumbens, Opioid Peptides, Rats, Rats, Sprague-Dawley, Stimulation, Chemical
Abstract

Orphanin FQ (OFQ; also known as nociceptin), the endogenous ligand of the opioid receptor-like receptor, injected intracerebroventricularly (i.c.v.) decreases basal motor activity and basal extracellular levels of dopamine (DA) in the nucleus accumbens (Nuc Acc) in rats.

DOI10.1111/j.1553-2712.2011.01024.x
Alternate JournalPsychopharmacology (Berl.)