Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary.

TitleEffects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary.
Publication TypeJournal Article
Year of Publication1985
AuthorsLorenz, RG, Evans CJ, Barchas JD
JournalLife sciences
Volume37
Issue16
Pagination1523-8
Date Published1985 Oct 21
ISSN0024-3205
KeywordsAnimals, beta-Endorphin, Dehydration, Dynorphins, Endorphins, Enkephalin, Leucine, Enkephalins, Food Deprivation, hypothalamus, Male, Peptide Fragments, Pituitary Gland, Posterior, Protein Precursors, Rats, Rats, Inbred Strains
Abstract

Dehydration significantly reduced the concentration of immunoreactive dynorphin A(1-17), dynorphin A(1-8), alpha-neo-endorphin, beta-neo-endorphin, and leu-enkephalin in the rat pituitary posterior-intermediate lobe. A statistically significant increase in immunoreactive dynorphin A(1-8), alpha-neo-endorphin and leu-enkephalin was observed in the hypothalamus. Comparison of the molar ratios of dynorphin A(1-17): dynorphin A(1-8) and alpha-neo-endorphin: beta-neo-endorphin showed an altered profile of stored pro-dynorphin cleavage products in the posterior-intermediate lobe of the pituitary of dehydrated rats.

DOI10.1002/hipo.20954
Alternate JournalLife Sci.