Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B).
|Title||Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B).|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Loewy, RL, Pearson R, Vinogradov S, Bearden CE, Cannon TD|
|Date Published||2011 Jun|
|Keywords||Adolescent, Adult, Female, Humans, Male, Mass Screening, Predictive Value of Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Questionnaires, Reproducibility of Results, Schizophrenia, Young Adult|
In this study, we examined the preliminary concurrent validity of a brief version of the Prodromal Questionnaire (PQ-B), a self-report screening measure for psychosis risk syndromes. Adolescents and young adults (N=141) who presented consecutively for clinical assessment to one of two early psychosis research clinics at the University of California, San Francisco and UC Los Angeles completed the PQ-B and the Structured Interview for Prodromal Syndromes (SIPS) at intake. Endorsement of three or more positive symptoms on the PQ-B differentiated between those with prodromal syndrome and psychotic syndrome diagnoses on the SIPS versus those with no SIPS diagnoses with 89% sensitivity, 58% specificity, and a positive Likelihood Ratio of 2.12. A Distress Score measuring the distress or impairment associated with endorsed positive symptoms increased the specificity to 68%, while retaining similar sensitivity of 88%. Agreement was very similar when participants with psychotic syndromes were excluded from the analyses. These results suggest that the PQ-B may be used as an effective, efficient self-report screen for prodromal psychosis syndromes when followed by diagnostic interview, in a two-stage evaluation process in help-seeking populations.
|Alternate Journal||Schizophr. Res.|