Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B).

TitlePsychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B).
Publication TypeJournal Article
Year of Publication2011
AuthorsLoewy, RL, Pearson R, Vinogradov S, Bearden CE, Cannon TD
JournalSchizophrenia research
Date Published2011 Jun
KeywordsAdolescent, Adult, Female, Humans, Male, Mass Screening, Predictive Value of Tests, Psychiatric Status Rating Scales, Psychotic Disorders, Questionnaires, Reproducibility of Results, Schizophrenia, Young Adult

In this study, we examined the preliminary concurrent validity of a brief version of the Prodromal Questionnaire (PQ-B), a self-report screening measure for psychosis risk syndromes. Adolescents and young adults (N=141) who presented consecutively for clinical assessment to one of two early psychosis research clinics at the University of California, San Francisco and UC Los Angeles completed the PQ-B and the Structured Interview for Prodromal Syndromes (SIPS) at intake. Endorsement of three or more positive symptoms on the PQ-B differentiated between those with prodromal syndrome and psychotic syndrome diagnoses on the SIPS versus those with no SIPS diagnoses with 89% sensitivity, 58% specificity, and a positive Likelihood Ratio of 2.12. A Distress Score measuring the distress or impairment associated with endorsed positive symptoms increased the specificity to 68%, while retaining similar sensitivity of 88%. Agreement was very similar when participants with psychotic syndromes were excluded from the analyses. These results suggest that the PQ-B may be used as an effective, efficient self-report screen for prodromal psychosis syndromes when followed by diagnostic interview, in a two-stage evaluation process in help-seeking populations.

Alternate JournalSchizophr. Res.