Leprosy and tuberculosis: the epidemiological consequences of cross-immunity

TitleLeprosy and tuberculosis: the epidemiological consequences of cross-immunity
Publication TypeJournal Article
Year of Publication1997
AuthorsLietman, T, Porco T, Blower S
JournalAm J Public Health
Volume87
Pagination1923-7
KeywordsLeprosy, Tuberculosis
Abstract

OBJECTIVES: This study tested the hypothesis, first proposed by Chaussinand, that individual-level immunity acquired from exposure to tuberculosis may have contributed to the disappearance of leprosy from western Europe. METHODS: The epidemiological consequences of cross-immunity were assessed by the formulation of a mathematical model of the transmission dynamics of tuberculosis and leprosy. RESULTS: The conditions under which Mycobacterium tuberculosis could have eradicated Mycobacterium leprae were derived in terms of the basic reproductive rates of the two infections and the degree of cross-immunity. CONCLUSIONS: If the degree of cross-immunity between two diseases within an individual is known, then the epidemiological consequences of this cross-immunity can be assessed with transmission modeling. The results of this analysis, in combination with previous estimates of the basic reproductive rate of tuberculosis and degree of cross-immunity, imply that tuberculosis could have contributed to the decline of leprosy if the basic reproductive rate of leprosy was low.

URLhttp://www.semel.ucla.edu/sites/all/files/biomedicalmodeling/pdf/leprosy.pdf