An open pilot study of the combination of escitalopram and bupropion-SR for outpatients with major depressive disorder.

TitleAn open pilot study of the combination of escitalopram and bupropion-SR for outpatients with major depressive disorder.
Publication TypeJournal Article
Year of Publication2008
AuthorsLeuchter, AF, Lesser IM, Trivedi MH, Rush JA, Morris DW, Warden D, Fava M, Wisniewski SR, Luther JF, Perales M, Gaynes BN, Stewart JW
JournalJournal of psychiatric practice
Volume14
Issue5
Pagination271-80
Date Published2008 Sep
ISSN1538-1145
KeywordsAdolescent, Adult, Aged, Ambulatory Care, Antidepressive Agents, Second-Generation, Bupropion, Citalopram, Delayed-Action Preparations, Depressive Disorder, Major, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Pilot Projects, Serotonin Uptake Inhibitors, Young Adult
Abstract

Monotherapy with a selective serotonin reuptake inhibitor (SSRI) is the most common initial treatment for major depressive disorder (MDD), but this monotherapy leads to remission in fewer than a third of patients. The combination of the SSRI escitalopram and bupropion-SR is commonly used for treating patients with MDD who have had an inadequate response to antidepressant monotherapy. This pilot study was conducted to evaluate this combination in the treatment of MDD in patients with chronic or recurrent MDD to estimate safety, tolerability, and remission rates.

DOI10.1111/j.1530-0277.2011.01591.x
Alternate JournalJ Psychiatr Pract