An open pilot study of the combination of escitalopram and bupropion-SR for outpatients with major depressive disorder.
|Title||An open pilot study of the combination of escitalopram and bupropion-SR for outpatients with major depressive disorder.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Leuchter, AF, Lesser IM, Trivedi MH, Rush JA, Morris DW, Warden D, Fava M, Wisniewski SR, Luther JF, Perales M, Gaynes BN, Stewart JW|
|Journal||Journal of psychiatric practice|
|Date Published||2008 Sep|
|Keywords||Adolescent, Adult, Aged, Ambulatory Care, Antidepressive Agents, Second-Generation, Bupropion, Citalopram, Delayed-Action Preparations, Depressive Disorder, Major, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Pilot Projects, Serotonin Uptake Inhibitors, Young Adult|
Monotherapy with a selective serotonin reuptake inhibitor (SSRI) is the most common initial treatment for major depressive disorder (MDD), but this monotherapy leads to remission in fewer than a third of patients. The combination of the SSRI escitalopram and bupropion-SR is commonly used for treating patients with MDD who have had an inadequate response to antidepressant monotherapy. This pilot study was conducted to evaluate this combination in the treatment of MDD in patients with chronic or recurrent MDD to estimate safety, tolerability, and remission rates.
|Alternate Journal||J Psychiatr Pract|