Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity.
|Title||Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Lee, B, London ED, Poldrack RA, Farahi J, Nacca A, Monterosso JR, Mumford JA, Bokarius AV, Dahlbom M, Mukherjee J, Bilder RM, Brody AL, Mandelkern MA|
|Journal||The Journal of neuroscience : the official journal of the Society for Neuroscience|
|Date Published||2009 Nov 25|
|Keywords||Adult, Amphetamine-Related Disorders, Basal Ganglia, Biological Markers, Caudate Nucleus, Corpus Striatum, Dopamine, Dopamine Uptake Inhibitors, Down-Regulation, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Male, Methamphetamine, Neuropsychological Tests, Nucleus Accumbens, Positron-Emission Tomography, Putamen, Receptors, Dopamine D2, Receptors, Dopamine D3, Young Adult|
While methamphetamine addiction has been associated with both impulsivity and striatal dopamine D(2)/D(3) receptor deficits, human studies have not directly linked the latter two entities. We therefore compared methamphetamine-dependent and healthy control subjects using the Barratt Impulsiveness Scale (version 11, BIS-11) and positron emission tomography with [(18)F]fallypride to measure striatal dopamine D(2)/D(3) receptor availability. The methamphetamine-dependent subjects reported recent use of the drug 3.3 g per week, and a history of using methamphetamine, on average, for 12.5 years. They had higher scores than healthy control subjects on all BIS-11 impulsiveness subscales (p < 0.001). Volume-of-interest analysis found lower striatal D(2)/D(3) receptor availability in methamphetamine-dependent than in healthy control subjects (p < 0.01) and a negative relationship between impulsiveness and striatal D(2)/D(3) receptor availability in the caudate nucleus and nucleus accumbens that reached statistical significance in methamphetamine-dependent subjects. Combining data from both groups, voxelwise analysis indicated that impulsiveness was related to D(2)/D(3) receptor availability in left caudate nucleus and right lateral putamen/claustrum (p < 0.05, determined by threshold-free cluster enhancement). In separate group analyses, correlations involving the head and body of the caudate and the putamen of methamphetamine-dependent subjects and the lateral putamen/claustrum of control subjects were observed at a weaker threshold (p < 0.12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction.
|Alternate Journal||J. Neurosci.|