Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults.

TitleDepression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults.
Publication TypeJournal Article
Year of Publication2009
AuthorsLavretsky, H, Siddarth P, Kepe V, Ercoli LM, Miller KJ, Burggren AC, Bookheimer SY, Huang S-C, Barrio JR, Small GW
JournalThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Volume17
Issue6
Pagination493-502
Date Published2009 Jun
ISSN1545-7214
KeywordsAged, Aged, 80 and over, Amyloid, Anxiety, Brain, cerebral cortex, Cognition Disorders, Depression, Female, Humans, Injections, Intravenous, Magnetic Resonance Imaging, Male, Middle Aged, Neurofibrillary Tangles, Nitriles, Plaque, Amyloid, Positron-Emission Tomography
Abstract

Amyloid senile plaques and tau neurofibrillary tangles are neuropathologic hallmarks of Alzheimer disease, which may be associated with mild cognitive impairment (MCI) or mood and anxiety symptoms years before the dementia diagnosis. To address this issue, the authors obtained positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), a molecule that binds to amyloid plaques and neurofibrillary tangles, to determine whether symptoms of depression and anxiety in nondemented subjects were associated with increased FDDNP-PET binding values.

Alternate JournalAm J Geriatr Psychiatry