Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.
|Title||Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Lavretsky, H, Ercoli L, Siddarth P, Bookheimer S, Miller K, Small G|
|Journal||The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry|
|Date Published||2003 Nov-Dec|
|Keywords||Aged, Aged, 80 and over, Alleles, Apolipoproteins E, Cognition Disorders, Dementia, Depression, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Risk Factors, Severity of Illness Index|
Because the apolipoprotein epsilon4 (APOE-epsilon4) allele or depressive symptoms may increase the risk for development of Alzheimer disease (AD), the authors assessed APOE-epsilon4 status, baseline level of depressive symptoms, and subsequent cognitive decline in middle-aged and older persons without dementia.
|Alternate Journal||Am J Geriatr Psychiatry|