Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.

TitleApolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.
Publication TypeJournal Article
Year of Publication2003
AuthorsLavretsky, H, Ercoli L, Siddarth P, Bookheimer S, Miller K, Small G
JournalThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Volume11
Issue6
Pagination667-73
Date Published2003 Nov-Dec
ISSN1064-7481
KeywordsAged, Aged, 80 and over, Alleles, Apolipoproteins E, Cognition Disorders, Dementia, Depression, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Risk Factors, Severity of Illness Index
Abstract

Because the apolipoprotein epsilon4 (APOE-epsilon4) allele or depressive symptoms may increase the risk for development of Alzheimer disease (AD), the authors assessed APOE-epsilon4 status, baseline level of depressive symptoms, and subsequent cognitive decline in middle-aged and older persons without dementia.

Alternate JournalAm J Geriatr Psychiatry