Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior.

TitleHuman brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior.
Publication TypeJournal Article
Year of Publication2010
AuthorsKonopka, G, Geschwind DH
JournalNeuron
Volume68
Issue2
Pagination231-44
Date Published2010 Oct 21
ISSN1097-4199
KeywordsAnimals, Behavior, Biological Evolution, Brain, cognition, Evolution, Molecular, Gene Expression, Genomics, Humans, Phenotype
Abstract

The evolution of the human brain has resulted in numerous specialized features including higher cognitive processes such as language. Knowledge of whole-genome sequence and structural variation via high-throughput sequencing technology provides an unprecedented opportunity to view human evolution at high resolution. However, phenotype discovery is a critical component of these endeavors and the use of nontraditional model organisms will also be critical for piecing together a complete picture. Ultimately, the union of developmental studies of the brain with studies of unique phenotypes in a myriad of species will result in a more thorough model of the groundwork the human brain was built upon. Furthermore, these integrative approaches should provide important insights into human diseases.

DOI10.1038/nn.3115
Alternate JournalNeuron