Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior.
|Title||Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Konopka, G, Geschwind DH|
|Date Published||2010 Oct 21|
|Keywords||Animals, Behavior, Biological Evolution, Brain, cognition, Evolution, Molecular, Gene Expression, Genomics, Humans, Phenotype|
The evolution of the human brain has resulted in numerous specialized features including higher cognitive processes such as language. Knowledge of whole-genome sequence and structural variation via high-throughput sequencing technology provides an unprecedented opportunity to view human evolution at high resolution. However, phenotype discovery is a critical component of these endeavors and the use of nontraditional model organisms will also be critical for piecing together a complete picture. Ultimately, the union of developmental studies of the brain with studies of unique phenotypes in a myriad of species will result in a more thorough model of the groundwork the human brain was built upon. Furthermore, these integrative approaches should provide important insights into human diseases.