The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.

TitleThe HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.
Publication TypeJournal Article
Year of Publication2011
AuthorsKilpatrick, LA, Labus JS, Coveleskie K, Hammer C, Rappold G, Tillisch K, Bueller JA, Suyenobu B, Jarcho JM, McRoberts JA, Niesler B, Mayer EA
JournalGastroenterology
Volume140
Issue7
Pagination1943-51
Date Published2011 Jun
ISSN1528-0012
KeywordsAdult, Amygdala, Anxiety, Brain Mapping, Case-Control Studies, Emotions, Facial Expression, Female, Genetic Predisposition to Disease, Humans, Irritable Bowel Syndrome, Los Angeles, Magnetic Resonance Imaging, Neuropsychological Tests, Phenotype, Polymorphism, Single Nucleotide, Receptors, Serotonin, 5-HT3, Severity of Illness Index
Abstract

5-Hydroxytryptamine (5-HT)3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. Their therapeutic effects are related, in part, to reducing amygdala engagement during expected visceral pain. A single nucleotide polymorphism in HTR3A, c.-42C>T;(C178T; rs1062613), is associated with altered reactivity of the amygdala during emotional face processing in healthy subjects (controls). We evaluated the influence of this single nucleotide polymorphism on amygdala reactivity to emotional faces and nonemotional stimuli in female patients with IBS and controls.

Alternate JournalGastroenterology