Reduced left hemispheric white matter volume in twins with bipolar I disorder.

TitleReduced left hemispheric white matter volume in twins with bipolar I disorder.
Publication TypeJournal Article
Year of Publication2003
AuthorsKieseppä, T, van Erp TGM, Haukka J, Partonen T, Cannon TD, Poutanen V-P, Kaprio J, Lönnqvist J
JournalBiological psychiatry
Volume54
Issue9
Pagination896-905
Date Published2003 Nov 1
ISSN0006-3223
KeywordsAdult, Axons, Bipolar disorder, Brain, Case-Control Studies, Cohort Studies, Diseases in Twins, Female, Finland, Functional Laterality, Genetic Predisposition to Disease, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Registries
Abstract

Although the heritability of bipolar I disorder (BPI) is high, few magnetic resonance imaging (MRI) studies of siblings of bipolar patients exist. We performed MRI brain scans on a nationwide sample of twins with BPI, as well as on their co-twins and a demographically balanced sample of control twin subjects, to detect any structural alterations related to the disorder and to the increased genetic risk.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalBiol. Psychiatry