Reduced left hemispheric white matter volume in twins with bipolar I disorder.
|Title||Reduced left hemispheric white matter volume in twins with bipolar I disorder.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Kieseppä, T, van Erp TGM, Haukka J, Partonen T, Cannon TD, Poutanen V-P, Kaprio J, Lönnqvist J|
|Date Published||2003 Nov 1|
|Keywords||Adult, Axons, Bipolar disorder, Brain, Case-Control Studies, Cohort Studies, Diseases in Twins, Female, Finland, Functional Laterality, Genetic Predisposition to Disease, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Registries|
Although the heritability of bipolar I disorder (BPI) is high, few magnetic resonance imaging (MRI) studies of siblings of bipolar patients exist. We performed MRI brain scans on a nationwide sample of twins with BPI, as well as on their co-twins and a demographically balanced sample of control twin subjects, to detect any structural alterations related to the disorder and to the increased genetic risk.
|Alternate Journal||Biol. Psychiatry|