White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis.

TitleWhite matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis.
Publication TypeJournal Article
Year of Publication2009
AuthorsKarlsgodt, KH, Niendam TA, Bearden CE, Cannon TD
JournalBiological psychiatry
Volume66
Issue6
Pagination562-9
Date Published2009 Sep 15
ISSN1873-2402
KeywordsAdolescent, Anisotropy, Brain, Brain Mapping, Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging, Female, Follow-Up Studies, Humans, Male, Mental Disorders, Neuropsychological Tests, Predictive Value of Tests, Psychiatric Status Rating Scales, Risk, Social Behavior, Young Adult
Abstract

White matter microstructural disruptions have been observed in patients with schizophrenia. However, whether changes exist prior to disease onset or in high-risk individuals is unclear. Here, we investigated white matter integrity, as assessed by diffusion tensor imaging (DTI), in individuals at ultra-high risk for psychosis (UHR) relative to healthy control subjects (HC) and the relationship between baseline DTI measures and functional outcome over time.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalBiol. Psychiatry