White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis.
|Title||White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Karlsgodt, KH, Niendam TA, Bearden CE, Cannon TD|
|Date Published||2009 Sep 15|
|Keywords||Adolescent, Anisotropy, Brain, Brain Mapping, Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging, Female, Follow-Up Studies, Humans, Male, Mental Disorders, Neuropsychological Tests, Predictive Value of Tests, Psychiatric Status Rating Scales, Risk, Social Behavior, Young Adult|
White matter microstructural disruptions have been observed in patients with schizophrenia. However, whether changes exist prior to disease onset or in high-risk individuals is unclear. Here, we investigated white matter integrity, as assessed by diffusion tensor imaging (DTI), in individuals at ultra-high risk for psychosis (UHR) relative to healthy control subjects (HC) and the relationship between baseline DTI measures and functional outcome over time.
|Alternate Journal||Biol. Psychiatry|