Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia.

TitleDiffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia.
Publication TypeJournal Article
Year of Publication2008
AuthorsKarlsgodt, KH, van Erp TGM, Poldrack RA, Bearden CE, Nuechterlein KH, Cannon TD
JournalBiological psychiatry
Volume63
Issue5
Pagination512-8
Date Published2008 Mar 1
ISSN1873-2402
KeywordsActivities of Daily Living, Adolescent, Adult, Atrophy, Child, Cognition Disorders, Diffusion Magnetic Resonance Imaging, Discrimination Learning, Dominance, Cerebral, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Male, Memory, Short-Term, Nerve Fibers, Myelinated, Nerve Net, Neuropsychological Tests, Parietal Lobe, Pattern Recognition, Visual, Phonetics, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Verbal Learning
Abstract

Structural and functional abnormalities in frontal-parietal circuitry are thought to be associated with working memory (WM) deficits in patients with schizophrenia. This study examines whether recent-onset schizophrenia is associated with anatomical changes in the superior longitudinal fasciculus (SLF), the main frontal-parietal white matter connection, and whether the integrity of the SLF is related to WM performance.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalBiol. Psychiatry