Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats
| Title | Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | John, J, Ramanathan L, Siegel JM |
| Journal | The American Journal of Physiology |
| Start Page | R2041 |
| Issue | 295 |
| Date Published | 09/2008 |
| Keywords | biosensor, cortex, histamine, microdialysis, rapid eye movement sleep |
| Abstract | Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats. Am J Physiol Regul Integr Comp Physiol 295: R2041–R2049, 2008. First published September 24, 2008; doi:10.1152/ajpregu.90541.2008.— The histamine-containing posterior hypothalamic region (PH-TMN) plays a key role in sleep-wake regulation. We investigated rapid changes in glutamate release in the PH-TMN across the sleep-wake cycle with a glutamate biosensor that allows the measurement of glutamate levels at 1- to 4-s resolution. In the PH-TMN, glutamate levels increased in active waking (AW) and rapid eye movement (REM) sleep compared with quiet waking and nonrapid eye move- ment (NREM) sleep. There was a rapid (0.6 |
| DOI | 10.1152/ajpregu.90541.2008 |
