Systemic Administration of Hypocretin-1 Reduces Cataplexy and Normalizes Sleep and Waking Durations in Narcoleptic Dogs

TitleSystemic Administration of Hypocretin-1 Reduces Cataplexy and Normalizes Sleep and Waking Durations in Narcoleptic Dogs
Publication TypeJournal Article
Year of Publication2000
AuthorsJohn, J, Wu M-F, Siegel JM
JournalSleep Research Online
Volume3
Start Page23
Issue1
Date Published05/2000
Keywordsnarcolepsy
Abstract

Recent work has implicated the hypocretin (orexin) system in the genesis of narcolepsy. In the current study we demonstrate that
systemically administered hypocretin-1 (Hcrt-1) produces an increase in activity level, longer waking periods, a decrease in REM
sleep without change in nonREM sleep, reduced sleep fragmentation and a dose dependent reduction in cataplexy in canine
narcoleptics. Repeated administration of single daily doses of Hcrt-1 led to consolidation of waking and sleep periods and to a
complete loss of cataplexy for periods of three or more days after treatment in animals that were never asymptomatic under
control conditions. Systemic administration of Hcrt-1 may be an effective treatment for narcolepsy.