Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity.

TitlePositive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity.
Publication TypeJournal Article
Year of Publication2009
AuthorsJahromi, LB, Kasari CL, McCracken JT, Lee LS-Y, Aman MG, McDougle CJ, Scahill L, Tierney E, Arnold EL, Vitiello B, Ritz L, Witwer A, Kustan E, Ghuman J, Posey DJ
JournalJournal of autism and developmental disorders
Volume39
Issue3
Pagination395-404
Date Published2009 Mar
ISSN1573-3432
KeywordsAdolescent, Asperger Syndrome, Autistic Disorder, Central Nervous System Stimulants, Child, Child Development Disorders, Pervasive, Child, Preschool, Cross-Over Studies, Dose-Response Relationship, Drug, Female, Humans, Male, Methylphenidate, Psychiatric Status Rating Scales, Psychomotor Agitation, Social Behavior, Social Control, Informal, Treatment Outcome
Abstract

This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.

DOI10.1016/j.brat.2011.06.001
Alternate JournalJ Autism Dev Disord