Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity.
|Title||Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Jahromi, LB, Kasari CL, McCracken JT, Lee LS-Y, Aman MG, McDougle CJ, Scahill L, Tierney E, Arnold EL, Vitiello B, Ritz L, Witwer A, Kustan E, Ghuman J, Posey DJ|
|Journal||Journal of autism and developmental disorders|
|Date Published||2009 Mar|
|Keywords||Adolescent, Asperger Syndrome, Autistic Disorder, Central Nervous System Stimulants, Child, Child Development Disorders, Pervasive, Child, Preschool, Cross-Over Studies, Dose-Response Relationship, Drug, Female, Humans, Male, Methylphenidate, Psychiatric Status Rating Scales, Psychomotor Agitation, Social Behavior, Social Control, Informal, Treatment Outcome|
This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.
|Alternate Journal||J Autism Dev Disord|